BACKGROUND We examined if transcranial Doppler (TCD) flow findings at the site of intracranial occlusions predict outcomes of stroke patients receiving intravenous rt-PA treatment. SUBJECTS AND METHODS TCD detected residual flow with the Thrombolysis in Brain Ischemia (TIBI) grading system before intravenous rt-PA bolus in patients with acute arterial intracranial occlusion. Timing and comple...

BACKGROUND AND PURPOSE TIMI angiographic classification measures coronary residual flow and recanalization. We developed a Thrombolysis in Brain Ischemia (TIBI) classification by using transcranial Doppler (TCD) to noninvasively monitor intracranial vessel residual flow signals. We examined whether the emergent TCD TIBI classification correlated with stroke severity and outcome in patients trea...

OBJECTIVE To determine clinical, neuroradiological or ultrasonographic parameters associated with early recanalization and clinical outcome in patients treated with intravenous (IVT) or combined intravenous-intra-arterial (IVT-IAT) thrombolysis. METHODS From 2004 to 2007, all consecutive ischemic stroke patients admitted within a 3-hour window and who underwent thrombolytic therapy were revie...

BACKGROUND AND PURPOSE Determine feasibility and safety of intravenous (IV) versus combined (IV-IA [intra-arterial]) thrombolysis guided by transcranial color-coded duplex sonography (TCCD). METHODS Thirty-three patients eligible for IV thrombolysis, within 3 hours of onset of symptoms, with occlusion in middle cerebral artery territory (TCCD monitoring, thrombolysis in brain ischemia [TIBI] ...

In populations with a high (≥14) median National Institute of Health Stroke Score (NIHSS), a normal finding of Thrombolysis in Brain Ischemia grade 5 (TIBI 5) in the artery of interest has been reported to be an unusual finding when transcranial ultrasound is performed during thrombolysis. In such instances, a stroke mimic can be suspected, but there are alternative pathophysiological explanati...

BACKGROUND AND PURPOSE We sought to evaluate the diagnostic accuracy of ultrasound criteria for recanalization during real-time transcranial Doppler monitoring of intra-arterial reperfusion procedures in acute ischemic stroke patients in an international, multicenter study. METHODS Consecutive acute ischemic stroke patients with proximal intracranial occlusions underwent intra-arterial reperf...

In the late 1990s Allan Robinson developed a theory of NPZ interactions in a laminar upwelling flow field. His approach was to use the advection reaction (AR) equation in a Lagrangian coordinate system. Recently, his theory was extended to turbulent flow by applying a probability density function to the solution of the AR equation. A review of this work is presented as well as new work examinin...

Background: Over the last years, more and more biological data became available. Besides the pure amount of new data, also its dimensionality—the number of di erent attributes per data point—increased. Recently, especially the amount of data on chromatin and its modifications increased considerably. In the field of epigenetics, appropriate visualization tools designed for highlighting the di er...

Title: Magnetic Resonance Adenosine Perfusion Imaging as Gatekeeper of Invasive Coronary Intervention (MAGnet): study protocol for a randomized controlled trial Authors: Dominik Buckert ([email protected]) Simon Witzel ([email protected]) Maciej Cieslik ([email protected]) Raid Tibi ([email protected]) Wolfgang Rottbauer ([email protected]...

A nonlinear model for biological and physical dynamical interactions in a laminar flow field being upwelled into the mixed layer Robinson(1999) (Fig 1, below) has been extended to turbulent flow (Goodman and Robinson, 2007). The approach of the Goodman and Robinson theory has been to develop a probability density function (pdf) for the turbulent displacement field and use that to calculate the ...